The Effect of Magnesium Sulfate Administration At Day of Embryo Transfer on Improving Subendometrial Blood Flow, Endometrial Receptivity ,Implantation Rate and Clinical  Pregnancy Rate.

Iqbal Fahad; Lubna Amer Amer Al-Anbari; Muayad S. Abbood

doi:10.28969/IJEIR.v12.i2.r5.22

Authors

Iqbal Fahad "High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq"
Lubna A. Al-Anbari The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies
Muayad S. Abbood The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies

DOI:

https://doi.org/10.28969/IJEIR.v12.i2.r5.22

Keywords:

Embryo trsansfere, Magnesium sulfate, Contraction, Clinical pregnancy rate, ART

Abstract

For successful implantation, a high-quality embryo, receptive
endometrium, and tight communication between the two are required. The
lack of uterine contractions during embryo transfer is one of the
characteristics that greatly affects endometrial receptivity. This is because it
has been observed that ET may cause uterine contractions, which may be
harmful to embryonic apposition and endometrial blood flow .The aim of this
study was to assess how magnesium sulfate administration on the day of
embryo transfer improve sub endometrial blood flow, endometrial receptivity,
and increase implantation rate and clinical pregnancy rate . Eighty infertile
women undergoing ART cycles participated in this prospective. Recombinant
FSH (Gonal-F) was used in a controlled ovarian hyperstimulation technique.
The first group A (n=40) got a 4gm infusion of magnesium sulfate, while the
second placebo control group B (n=40) received 200ml of 5% glucose water
as a placebo, respectively. While there were no significant changes in body
mass index (BMI), endometrial thickness, number of transferred embryos, or
embryo transfer day, significant variations were seen in patient mean age
(p<0.001) and mean number of grades I embryo (P=0.003). It was
significantly different after magnesium sulfate administration with the lowest
value in magnesium sulfate group (P=0.024; P <0.001 and P <0.001
respectively). Implantation rate and clinical pregnancy rate both increased
after drugs administration although it was non- significant (P= 0.106 and P=
0.348 respectively). It appears that magnesium sulfate injection before to
embryo transfer can significantly increase sub endometrial vascularity and
endometrial receptivity and improving implantation rate and clinical
pregnancy rate non significantly in ICSI cycles by lowering uterine muscular

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Author Biography

Lubna A. Al-Anbari, The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies

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