The Comparison Between The Effect of Different Medical Drugs used To Improve Endometrial Receptivity in patients with Thin Poorly Vascularized Endometrium

Authors

  • Alaa T. Tawfeeq The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies
  • Muayad S. Abbood The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies
  • Mufeda AL-Ammar The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies

DOI:

https://doi.org/10.28969/IJEIR.v13.i2.r8.23

Keywords:

endometrial blood flow, Implantation

Abstract

In a perfect world, the peak of receptivity of the endometrial lining would
occur simultaneously with the entry into the uterine cavity of a healthy
blastocyst, which would then be able to adhere, attach, invade, and develop
protected until the time of delivery. This would be the ideal scenario. The
study was carried out on 200 infertile women who have thin , poorly
vascularized endometrium, those patients were divided into five groups ; 40
patients in each group, group A received esterofem oral, group B received
vagifem vaginal tablets, group C received sildenafil citrate gel, group D
received pentoxifylline oral and group E received 4 grams of pentoxifylline
vaginal gel. The endometrial thickness, vascularity zones, sub endometrial
flow, and both uterine arteries resistance and pulsatility indices were assessed
at the middle of the menstrual cycle (day 11–14) on a monthly basis for six
cycles or until a positive pregnancy test was obtained. Pentoxifylline vaginal
gel, pentoxifylline+ vitamin E capsule, and sildenafil vaginal gel have
improved the vascularity indeces of endometrium and uterine arteries, while
the vagifem and esterofem were less effective in terms of improving the
vascularity indeces of endometrium and uterine arteries. The study also
showed that 57.5% of women succeed to get pregnant after six months of
receiving pentoxifylline vaginal gel, 35% of women succeed to get pregnant
after six months of Pentoxifylline+vit E, while 22.5% of women succeed to
get pregnant after six months of sildenafil, about 10% of women got pregnant
after six months of vagifem, and finally 2.5% of women got pregnant after six
months of receiving estrofem tablets. It was discovered that pentoxifylline
vaginal gel, pentoxifylline tablet plus vitamin E capsule, and sildenafil
vaginal gel were able to improve the vascularity index of the endometrium,
the uterine arteries and endometrial thickness, and enhance the pregnancy
rates in patients with thin poorly vascularized endometrium.

References

Abbas, Y., Turco, M.Y., Burton, G.J. and Moffett, A., 2020. Investigation of human trophoblast invasion in vitro. Human Reproduction Update, 26(4), pp.501-513.

Afaf T, E. and Mohamed, S., 2020. Chronic endometritis in in vitro fertilization failure patients. Clinical Journal of Obstetrics and Gynecology, 3(2), pp.175-181.

Alaa, S., Al-Hilli, N. and Jwad, M., 2021. Effect of Administration of Single Dose GnRH Agonist in Luteal Phase on Implantation Rate of Fresh ICSI Cycles. Iraqi Journal of Embryos and Infertility Researches, 10(2), pp.1-14.

Al-Kady, M., Mostafa, M., Mansour, D., Mohamed, N., Ahmed, H. and Rushdy, E., 2021. Effect of Follicular Fluid Estradiol Level on Oocyte Quality, Fertilization and Pregnancy Outcome in Intracytoplasmic Sperm Injection Cycles. QJM: An International Journal of Medicine, 114(Supplement_1).

Published

2023-11-08

How to Cite

1.
T. Tawfeeq A, S. Abbood M, AL-Ammar M. The Comparison Between The Effect of Different Medical Drugs used To Improve Endometrial Receptivity in patients with Thin Poorly Vascularized Endometrium. IJEIR [Internet]. 2023 Nov. 8 [cited 2024 Apr. 20];13(2):99-115. Available from: https://ijeir.net/index.php/ijeir/article/view/89

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