Relation of serum and follicular level of GDF9 to oocyte quality, embryo quality and pregnancy rate
DOI:
https://doi.org/10.28969/IJEIR.v12.i1.r8.22Keywords:
GDF9, folliculogenesis, oocyte quality, oocyte secreted factors, ICSIAbstract
It is well known that oocyte quality is essential in the determination of
the developmental potential of the fertilized oocytes. The oocyte
developmental potential decreases in all species with increasing age.
Use of serum and follicular fluid concentration of GDF9 as biomarkers
of oocyte and embryo quality and their relation to pregnancy rate.
Eighty-eight women were included in this study are selected from those
undergoing intra-cytoplasmic sperm injection.
Positive pregnancy was achieved by 14 women. The difference in mean
serum and follicular GDF9 between pregnant and non-pregnant women
was not significant. MI oocyte count was not significantly correlated to
serum and follicular GDF9 (p > 0.05). MII oocyte count showed a nonsignificant correlation to serum and follicular GDF9 (p > 0.05). Grade 1
embryo count showed a non-significant correlation to serum and
follicular GDF9. Grade 2 embryo count showed a non-significant
correlation to serum and follicular GDF9. Also, grade 3 embryo count
showed a non-significant correlation to serum and follicular GDF9.
The current study revealed that serum and follicular GDF9 could not be
used as indicators for oocyte maturity, embryo quality, or pregnancy rate
Downloads
References
Kankanam Gamage, U. S., Hashimoto, S., Miyamoto, Y., Nakano, T., Yamanaka, M., Koike, A., ... & Morimoto, Y. (2022). Mitochondria Transfer from Adipose Stem Cells Improves the Developmental Potential of Cryopreserved Oocytes. Biomolecules, 12(7), 1008.
Carson, S. A., & Kallen, A. N. (2021). Diagnosis and management of infertility: a review. Jama, 326(1), 65-76.
Deshpande, P. S., & Gupta, A. S. (2019). Causes and prevalence of factors causing infertility in a public health facility. Journal of human reproductive sciences, 12(4), 287.
Song, Y., & Li, R. (2021). Effects of Environment and Lifestyle Factors on Anovulatory Disorder. In Environment and Female Reproductive Health (pp. 113-136). Springer, Singapore.
Rakhimovna, K. D., Amirovna, T. S., & Abdumuminovna, S. Z. (2022). Modern possibilities of a differentiated approach to the treatment of infertility in women with polycystic ovary syndrome. ACADEMICIA: An International Multidisciplinary Research Journal, 12(5), 267-278.
Adhikari, D., Lee, I. W., Yuen, W. S., & Carroll, J. (2022). Oocyte mitochondria—key regulators of oocyte function and potential therapeutic targets for improving fertility. Biology of Reproduction , 106(2), 366-377.
Sanfins, A., Rodrigues, P., & Albertini, D. F. (2018). GDF-9 and BMP-15 direct the follicle symphony. Journal of assisted reproduction and genetics, 35(10), 1741-1750.
Da Broi, M. G., Giorgi, V. S. I., Wang, F., Keefe, D. L., Albertini, D., & Navarro, P. A. (2018). Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications. Journal of assisted reproduction and genetics, 35(5), 735-751.
Victoria, M., Labrosse, J., Krief, F., Cédrin-Durnerin, I., Comtet, M., & Grynberg, M. (2019). Anti Müllerian hormone: more than a biomarker of female reproductive function. Journal of gynecology obstetrics and human reproduction, 48(1), 19-24.
DAYANIR, D., Ruso, H., Kalem, Z., Gurgan, T., & Ozogul, C. (2019). Rewarding Conversation Between Oocyte and Cumulus Cells Directs the Process of Folliculogenesis. GAZI MEDICAL JOURNAL, 30(4).
De Geyter, C., Calhaz-Jorge, C., Kupka, M. S., Wyns, C., Mocanu, E., Motrenko, T., ... & Goossens, V. (2018). ART in Europe, 2014: results generated from European registries by ESHRE: The European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE). Human reproduction, 33(9), 1586-1601.
Jassim, W. H., Al-Obaidi, M. T., & Ghazi, H. F. (2021). The Effect of Intrauterine Infusion of Peripheral Blood Mononuclear Cells Culture on Subendometrial Blood Flow in Patients Undergoing ICSI Cycles. Iraqi Journal of Embryos and Infertility Researches, 10(2), 53-72
Maya, W. D. C., Du Plessis, S. S., & Velilla, P. A. (2020). SARS-CoV-2 and the testis: similarity with other viruses and routes of infection. Reproductive biomedicine online, 40(6), 763-76
Duarte‐Neto, A. N., Teixeira, T. A., Caldini, E. G., Kanamura, C. T., Gomes‐Gouvêa, M. S., Dos Santos, A. B., ... & Hallak, J. (2022). Testicular pathology in fatal COVID‐19: A descriptive autopsy study. Andrology, 10(1), 13-23
Li, J., Li, C., Liu, X., Yang, J., Zhang, Q., Han, W., & Huang, G. (2022). GDF9 concentration in embryo culture medium is linked to human embryo quality and viability. Journal of Assisted Reproduction and Genetics, 39(1), 117-125.
Li, Y., Li, R. Q., Ou, S. B., Zhang, N. F., Ren, L., Wei, L. N., ... & Yang, D. Z. (2014). Increased GDF9 and BMP15 mRNA levels in cumulus granulosa cells correlate with oocyte maturation, fertilization, and embryo quality in humans. Reproductive biology and Endocrinology, 12(1), 1-9.
Chandra, V., & Sharma, G. T. (2020). In vitro strategies to enhance oocyte developmental competence. Frontiers in Bioscience-Scholar, 12(1), 116-136.
Michael, J. D., Campanile, G., & Baruselli, P. S. (2020). Transforming growth factor-β superfamily and interferon-τ in ovarian function and embryo development in female cattle: review of biology and application. Reproduction, Fertility and Development, 32(6), 539-552.
Yueh, W. T., Singh, V. P., & Gerton, J. L. (2021). Maternal Smc3 protects the integrity of the zygotic genome through DNA replication and mitosis. Development, 148(24), dev199800.
Daneshjou, D., Mehranjani, M. S., Zadehmodarres, S., Shariatzadeh , S. M. A., & Mofarahe, Z. S. (2022). Sitagliptin/metformin improves the fertilization rate and embryo quality in polycystic ovary syndrome patients through increasing the expression of GDF9 and BMP15: A new alternative to metformin (a randomized trial). Journal of Reproductive Immunology, 150, 103499.
Kahraman, S., Çetinkaya, C. P., Çetinkaya, M., Tüfekçi, M. A., Ekmekçi, C. G., & Montag, M. (2018). Is there a correlation between follicle size and gene expression in cumulus cells and is gene expression an indicator of embryo development?. Reproductive Biology and Endocrinology, 16(1), 1-10.
Li, J., Li, C., Liu, X., Yang, J., Zhang, Q., Han, W., & Huang, G. (2022). GDF9 concentration in embryo culture medium is linked to human embryo quality and viability. Journal of Assisted Reproduction and Genetics, 39(1), 117-125.
Mohsenzadeh, M., Khalili, M. A., Anbari, F., & Vatanparast, M. (2022). High efficiency of homemade culture medium supplemented with GDF9-β in human oocytes for rescue in vitro maturation. Korean Journal of Fertility and Sterility.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Zainab Hassan Hashim, Lubna Amer Al-Anbari, Estabraq Al-Wasiti
This work is licensed under a Creative Commons Attribution 4.0 International License.
