Relation of serum and follicular level of GDF9 to oocyte quality, embryo quality and pregnancy rate
DOI:
https://doi.org/10.28969/IJEIR.v12.i1.r8.22Keywords:
GDF9, folliculogenesis, oocyte quality, oocyte secreted factors, ICSIAbstract
It is well known that oocyte quality is essential in the determination of
the developmental potential of the fertilized oocytes. The oocyte
developmental potential decreases in all species with increasing age.
Use of serum and follicular fluid concentration of GDF9 as biomarkers
of oocyte and embryo quality and their relation to pregnancy rate.
Eighty-eight women were included in this study are selected from those
undergoing intra-cytoplasmic sperm injection.
Positive pregnancy was achieved by 14 women. The difference in mean
serum and follicular GDF9 between pregnant and non-pregnant women
was not significant. MI oocyte count was not significantly correlated to
serum and follicular GDF9 (p > 0.05). MII oocyte count showed a nonsignificant correlation to serum and follicular GDF9 (p > 0.05). Grade 1
embryo count showed a non-significant correlation to serum and
follicular GDF9. Grade 2 embryo count showed a non-significant
correlation to serum and follicular GDF9. Also, grade 3 embryo count
showed a non-significant correlation to serum and follicular GDF9.
The current study revealed that serum and follicular GDF9 could not be
used as indicators for oocyte maturity, embryo quality, or pregnancy rate
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