Effects of PRP Intratesticle Injection in Non-Obstructive Azoospermic Infertile Men in vivo on Spermatogenesis and Reproductive Hormonal Levels(FSH and LH)
Keywords:NOA(Non Obstructive Azoospermia) Azoospermia, and Platelet Rich Plasma
Non-obstructive azoospermia (NOA) is the absence of sperm in infertile
men ejaculate as a result of significant spermatogenesis defects or
hormonal malfunction. PRP intratesticular injection may be employed in
assisted reproductive technology as a therapeutic effect for this problem.
The aim is to assess the level of spermatogenesis and reproductive
hormones after PRP autologous intratesticular injection. 50 nonabstructive azoospermia infertile men participated in the current study.
The patients were given an intra-testicular injection of platelet-rich
plasma using a 1 ml syringe; FSH LH hormonal levels were estimated; if
there was no sperm count, the patient should be prepared for a testicular
biopsy by the expert doctor. Small number of sperm may be discovered
during a biopsy while the testes are being examined in the lab. The
therapeutic benefits were seen in 15 patients 3-4 months after using
autologous platelet-rich plasma. The results showed that there was a
highly significant difference in FSH and LH hormonal levels after PRP
injection P(0.001). PRP can help non-obstructive azoospermic infertile
males with their testis' structural and functional dysfunction.
Kumar R (2013) Medical management of non-obstructive azoospermia. Clinics (Sao Paulo) 68: p-75-79.
Hendriks S, Dancet EA, Meissner A, van der Veen F, Mochtar MH,. (2014) Perspectives of infertile men on future stem cell treatments for nonobstructive azoospermia. Reprod Biomed Online 28:p- 650-657.13.
Chang Y, Li J, Chen Y, Wei L, Yang X, et al. (2015) Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med 8: p-1286-1290.
Wang HL, Avila G (2007) Platelet Rich Plasma: Myth or Reality? Eur J Dent 1: p-192-194.
Pantos K, Nitsos N, Kokkali G, Vaxevanoglou T, Markomichali C, et al. (2016) Ovarian rejuvenation and folliculogenesis reactivation in peri-menopausal women after autologous platelet-rich plasma treatment. P-401.
Gudelci, M.D.,Yigit Cakiroglu, M.D.,Aysen Yuceturk, M.D,Bulent Tiras, M.D,Ali Rıza Kural, M.D.,Emre Seli, M.D., (2021) ,| The effect of intratesticular injection of autologous platelet rich plasma (prp) on sperm retrieval rates and ivf outcomes in men with non-obstructive azoospermia and history of failed testicular sperm extraction, volume 116
Gardner DK,et al., Lane M, Watson AJ. A laboratory guide to the mammalian embryo. New York: Oxford University Press; 2004.p.76-85
Plant TM, Marshall GR. 2001;The functional significance of FSH in spermatogenesis and the control of its secretion in male primates. Endocr Rev, n22(6):pp 764-786.
Alio JL, Arnalich-Montiel F, Rodriguez AE (2012) The role of "eye platelet rich plasma" (E-PRP) for wound healing in ophthalmology. Curr Pharm Biotechnol 13:p- 1257-1265.
Anitua E, de la Fuente M, Ferrando M, Quintana F, Larreategui Z, et al. (2016) Biological effects of plasma rich in growth factors (PRGF) on human endometrial fibroblasts. Eur J Obstet Gynecol Reprod Biol 206:p- 125-130.
Borrione P, Gianfrancesco AD, Pereira MT, Pigozzi F (2010) Platelet-rich plasma in muscle healing. Am J Phys Med Rehabil 89: p-854-861.
Kraemer WJ, Rogol AD. The endocrine system in sports and exercise. Malden, Massachusetts: Blackwell Publishing; 2005. no. 30.p 978-1-4051.
Lenz J, Celander D, Crowther RL, Patarca R, Perkins DW, (1984) Determination of the leukaemogenicity of a murine retrovirus by sequences within the long terminal repeat. Nature 308: p-467-470.
Sekerci CA, Tanidir Y, Sener TE, Sener G, Cevik O, et al. (2017) Effects of platelet-rich plasma against experimental ischemia/reperfusion injury in rat testis. J Pediatr Urol 13p-: 317.
Al-Nasser R, Zakwan Khrait* and Samer ,2018, The Effectiveness of Autol- ogous Platelet-Rich Plasma (PRP) in the Therapy of Infer- tile Men with Non-Abstractive Azoospermia HSOA Journal of Reproductive Medicine, Gynaecology .
World Health Organization (2010) WHO laboratory manual for the examination and processing of human semen, 5th ed. World Health Organization, Geneva.
How to Cite
Copyright (c) 2023 Rasha Hassan, Ula Al-kawaz, Rana S.Al.Saadi
This work is licensed under a Creative Commons Attribution 4.0 International License.