Effect of Bisphenol A Level In Serum and Follicular Fluid On ICSI OutCome
DOI:
https://doi.org/10.28969/IJEIR.v12.i1.r1.22Keywords:
Bisphenol A (BPA), Infertility, ICSIAbstract
Infertility is the disability of a couple to obtain pregnancy after one year of
sexual intercourse that is unprotected and regular. Bisphenol A is an industrial
chemical spread worldwide, that is a raw material utilized in multiple
industries. Bisphenol A is assorted as an endocrine-disrupting chemical,
which can interfere with hormone activity. This study aimed to assess the
effect of BPA levels in serum on ICSI outcomes. The study was conducted at
the High Institute for Infertility Diagnosis and Assisted Reproductive
Technologies / Al-Nahrain University during the period from October 2021
to April 2022. sixty infertile women enrolled in this study. BPA levels were
analyzed through an enzyme-linked immunosorbent assay (ELISA)
technique. Mean serum BPA was not significantly higher in non-pregnant
women in comparison with that of pregnant women. Serum BPA was
positively correlated to immature oocytes (MI) and abnormal oocytes. Also,
BPA inversely correlated to Grade1 embryos and positively correlated to
Grade 3 embryos. Bisphenol A can be detected in sera of infertile female
undergoing ICSI. High BPA level in serum may impact oocyte quality and
embryo grading
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References
World Health Organization. WHO fact sheet on infertility. Global Reproductive Health. 2021 Apr 1;6(1):e52.
Vasilopoulos E, Fragkiadaki P, Kalliora C, Fragou D, Docea AO, Vakonaki E, Tsoukalas D, Calina D, Buga AM, Georgiadis G, Mamoulakis C. The association of female and male infertility with telomere length. International journal of molecular medicine. 2019 Aug 1;44(2):375-89.
Tsatsakis A, Docea AO, Constantin C, Calina D, Zlatian O, Nikolouzakis TK, Stivaktakis PD, Kalogeraki A, Liesivuori J, Tzanakakis G, Neagu M. Genotoxic, cytotoxic, and cytopathological effects in rats exposed for 18 months to a mixture of 13 chemicals in doses below NOAEL levels. Toxicology Letters. 2019 Nov 1;316:154-70.
Ohore OE, Zhang S. Endocrine disrupting effects of bisphenol A exposure and recent advances on its removal by water treatment systems. A review. Scientific African. 2019 Sep 1;5:e00135.
Husain Q, Qayyum S. Biological and enzymatic treatment of bisphenol A and other endocrine disrupting compounds: a review. Critical Reviews in Biotechnology. 2013 Sep 1;33(3):260-92.
Gao C, He H, Qiu W, Zheng Y, Chen Y, Hu S, Zhao X. Oxidative stress, endocrine disturbance, and immune interference in humans showed relationships to serum bisphenol concentrations in a dense industrial area. Environmental Science & Technology. 2021 Jan 26;55(3):1953-63.
Brede C, Fjeldal P, Skjevrak I, Herikstad H. Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushing. Food Additives & Contaminants. 2003 Jul 1;20(7):684-9.
Chen WY, Shen YP, Chen SC. Assessing bisphenol A (BPA) exposure risk from long-term dietary intakes in Taiwan. Science of the Total Environment. 2016 Feb 1;543:140-6.
Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA). Reproductive toxicology. 2007 Aug 1;24(2):139-77.
Hao J, Wang J, Zhao W, Ding L, Gao E, Yuan W. Effect of bisphenol A exposure on sex hormone level in occupational women. Wei Sheng yan jiu= Journal of Hygiene Research. 2011 May 1;40(3):312-4.
Asencio-Hernández, J., Kieffer, B. and Delsuc, M.A., 2016. NMR WaterLOGSY reveals weak binding of bisphenol A with amyloid fibers of a conserved 11 residue peptide from androgen receptor. Plos one, 11(9), p.e0161948.
Santangeli S, Maradonna F, Olivotto I, Piccinetti CC, Gioacchini G, Carnevali O. Effects of BPA on female reproductive function: The involvement of epigenetic mechanism. General and comparative endocrinology. 2017 May 1;245:122-6.
Souter I, Smith KW, Dimitriadis I, Ehrlich S, Williams PL, Calafat AM, Hauser R. The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments. Reproductive toxicology. 2013 Dec 1;42:224-31.
Zhang TY, Bu QZ, Su CY. Clinical Results of In Vitro Fertilization or Intracytoplasmic Sperm Injection Treatments in Women Aged 40 Years and above. Reproductive and Developmental Medicine. 2018 Jun 25;2(02):100-4.
Razi, M.H., Razi, Y., Sabeti, P., Esmailabad, S.G. and Pourmasumi, S., 2014. Correlation between women age and oocyte quality, embryo formation and pregnancy outcomes in assisted reproductive technology cycles: A retrospective analysis. Journal of Infertility and Reproductive Biology, 2(4), pp.108-114.
Fahad IA, Al-Murshedi SY, Al-Khafaji ZH. The Effect of Female Age and the Duration of Infertility on Intracytoplasmic Sperm Injection Outcomes. Magazine of Al-Kufa University for Biology. 2015;7(3):181-92.
Kahn LG, Philippat C, Nakayama SF, Slama R, Trasande L. Endocrine-disrupting chemicals: implications for human health. The lancet Diabetes & endocrinology. 2020 Aug 1;8(8):703-18.
Kahn LG, Philippat C, Nakayama SF, Slama R, Trasande L. Endocrine-disrupting chemicals: implications for human health. The lancet Diabetes & endocrinology. 2020 Aug 1;8(8):703-18.
Bin LI, Ning YA, Yu-ping GA. Association of serum and follicular fluid bisphenol A levels with pregnancy outcomes in patients undergoing in vitro fertilization-embryo transfer. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE). 2016 Oct 28;36(10):1451.
Huo X, Chen D, He Y, Zhu W, Zhou W, Zhang J. Bisphenol-A and female infertility: a possible role of gene-environment interactions. International journal of environmental research and public health. 2015 Sep;12(9):11101-16.
Pivonello C, Muscogiuri G, Nardone A, Garifalos F, Provvisiero DP, Verde N, De Angelis C, Conforti A, Piscopo M, Auriemma RS, Colao A. Bisphenol A: an emerging threat to female fertility. Reproductive Biology and Endocrinology. 2020 Dec;18(1):1-33.
Yenigül NN, Dilbaz S, Dilbaz B, Kaplanoğlu İ, Güçel F, Aldemir O, Baser E, Ozelci R, Tekin OM. The effect of plastic bottled water consumption on outcomes of ICSI cycles undertaken for unexplained infertility. Reproductive BioMedicine Online. 2021 Jul 1;43(1):91-9.
Poormoosavi SM, Behmanesh MA, Janati S, Najafzadehvarzi H. Level of bisphenol a in follicular fluid and serum and oocyte morphology in patients undergoing IVF treatment. Journal of family & reproductive health. 2019 Sep;13(3):154.
Lee YM, Hong YC, Ha M, Kim Y, Park H, Kim HS, Ha EH. Prenatal Bisphenol-A exposure affects fetal length growth by maternal glutathione transferase polymorphisms, and neonatal exposure affects child volume growth by sex: From multiregional prospective birth cohort MOCEH study. Science of the total environment. 2018 Jan 15;612:1433-41.
Hunt PA, Hassold TJ. Human female meiosis: what makes a good egg go bad?. Trends in Genetics. 2008 Feb 1;24(2):86-93.
Machtinger R, Combelles CM, Missmer SA, Correia KF, Williams P, Hauser R, Racowsky C. Bisphenol-A and human oocyte maturation in vitro. Human reproduction. 2013 Oct 1;28(10):2735-45.
Wang T, Han J, Duan X, Xiong B, Cui XS, Kim NH, Liu HL, Sun SC. The toxic effects and possible mechanisms of Bisphenol A on oocyte maturation of porcine in vitro. Oncotarget. 2016 May 31;7(22):32554.
Lenie S, Cortvrindt R, Eichenlaub-Ritter U, Smitz J. Continuous exposure to bisphenol A during in vitro follicular development induces meiotic abnormalities. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2008 Mar 12;651(1-2):71-81.
Fujimoto VY, Kim D, vom Saal FS, Lamb JD, Taylor JA, Bloom MS. Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vitro fertilization. Fertility and sterility. 2011 Apr 1;95(5):1816-9.
Syrkasheva A, Frankevich V, Kindysheva S, Starodubtseva N, Donnikov A , Dolgushina N. Bisphenol A in infertile patients: impact on assisted reproductive technologies outcomes.obstetrics and gynecology.2021; (5): 113-20.
Kim MJ, Park YJ. Bisphenols and thyroid hormone. Endocrinology and Metabolism. 2019 Dec 1;34(4):340-8.
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Copyright (c) 2022 Sarah Hamza, Muayad Abbood, Mufeda Jwad
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