Correlation of serum and follicular fluid EMMPRIN levels at day of ova pick up and embryo transfer to endometrial thickness and its effect on ICSI outcomes in fresh cycles
Keywords:EMMPRIN, Basigin, Serum, Follicular fluid, ICSI
EMMPRIN (Basigin) is a potent inducer of matrix metalloproteinases
(MMPs). Expression of EMMPRIN in the uterus has a very important
role in implantation of embryo, this study was conducted to evaluate the
relationship of pregnancy rates with EMMPRIN levels in follicular fluid
and serum of intracytoplasmic sperm injection patients. The study was
cross sectional study analyzed the serum and follicular fluid samples of
58 patients undergo ICSI procedure. The serum and follicular fluid
samples were collected from infertile women aged 20 to 42 years.
However, the levels of EMMPRIN were measured in the serum and
follicular fluid samples and these samples were obtained during oocytes
retrieval and another serum samples were collected at the day of embryo
transfer. All women have ovarian stimulation with recombinant follicle
stimulating hormone (FSH) at the second or third day of the cycle.
Result: The pregnancy rate was 27.6 %. The present study showed that
EMMPRIN in serum and follicular fluid at day of ova pickup and its level
at embryo transfer day, are significantly low in pregnant women (p <
0.05) compared to non-pregnant women. The statistical analysis showed
no significant correlation between serum and follicular fluid EMMPRIN
with endometrial thickness (p > 0.05).
EMMPRIN level can be used as a promising parameter for the prediction
of pregnancy rate in ICSI cycles
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Copyright (c) 2023 Methaq Almousa, Amal Abdulwahid Mohammed, Ali Ibrahim Rahim
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