the effect of in vitro exposure to certain metformin doses on the motility of human spermatozoa
DOI:
https://doi.org/10.28969/IJEIR.v12.i1.r5.22Keywords:
metformin, spermatozoa, motility, AMPKAbstract
Metformin is an anti-hyperglycemic medication used to treat type 2
diabetes mellitus. Regardless of its anti-diabetic effect, metformin has a
non-genomic action and it could be a beneficial additive to treat the sperm
which considered as transcriptionally dormant cell and also a molecule
that could rapidly adjust the metabolism of spermatozoa to adapt it to the
surrounding environment. Sixty-four normozoospermic semen sample
included in the study. Each sample incubated for 30 minutes with
metformin (2.5 and 0.5 µM) and SFA was conducted to each sample.
There was a significant decrease in total motility (progressive and nonprogressive)
in samples incubated with both concentrations compared
with the neat samples. While the samples incubated with 0.5 µM shows
a lower motility compared with 2.5 µM. Metformin significantly reduced
total motility of fresh spermatozoa at both concentrations.
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Copyright (c) 2022 Fatima Emad Al-Nashme , Wasan Adnan Al-Jubory
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