Effects of Activin A Hormone on Fertilization Capacity of PCOS Women Undergoing ICSI Cycle in Sample of Iraqi Women


  • Ghofran Khalial High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.
  • Wasan Adnan Abdulhameed High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.
  • Saad S. Al-Dujaily High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.




Infertility, Activin-A, Pregnancy outcome, PCOS, ICSI


Activin is a member of the transforming growth factor-beta superfamily and is a polypeptide growth factor. Activin regulates follicle growth, gonadotropin responsiveness, steroidogenesis, oocyte maturation, ovulation, and corpus luteum function in the ovary via a local autocrine/paracrine effect. Activin measurement A level in serum and follicular fluid during the preovulatry stage in PCOS women undergoing an IVF/ICSI cycle to predict fertilization capacity earlier Fifty infertile couples, 25 with PCOS and 25 without PCOS, who attended Al Nahrain University in Baghdad, Iraq's High Institute of Infertility Diagnosis and Assisted Reproductive Technologies. The females that participated were between the ages of 18 and 40. On the day of oocyte retrieval, the level of Activin A in serum and follicular fluid was measured. Activin A levels in PCOS women's serum (activin A=1274 77.9) and follicular fluid (activin A =1038 50.3) compared to non-PCOS women's serum (activin A=453 25.74) and follicular fluid (Activin A=450 23.73).  The study shows no correlation between activin A hormone with oocytes characteristics and fertilization rate in PCOS women with a significant increase of activin A hormone in the serum and FF of PCOS women compared to non PCOS women. Activin A level can predict a diagnosis of PCOS in addition to positive predictive pregnancy but not indicator of fertilization capacity in PCOS women.


 Al-Dujaily, S. S., & Shukry, N. T. (2019). Role of Serum Activin A and Granulocyte Macrophage-Colony Stimulating Factor in the Prediction of Pregnancy Outcome in PCOS and Non-PCOS Women Following ICSI. Indian Journal of Public Health Research & Development, 10(9). ‏

 Altun, T., Jindal, S., Greenseid, K., Shu, J., & Pal, L. (2011). Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. Journal of Assisted Reproduction and Genetics, 28(3), 245-251. ‏

 Ando, H. (2021). Activin. In Handbook of Hormones. Academic Press. ‏ pp. 559-562.

 Coticchio, G., Mignini Renzini, M., Novara, P. V., Lain, M., De Ponti, E., Turchi, D, Canto, M. (2018). Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability. Human Reproduction, 33(1), 23-31. ‏

 Cronk, B. C. (2019). How to use SPSS®: A step-by-step guide to analysis and interpretation. Routledge. ‏

 Duffy, J. M. N., Bhattacharya, S., Bhattacharya, S., Bofill, M., Collura, B., Curtis, C. (2020). Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study. Human Reproduction, 35(12), 2735-2745. ‏

 Escobar-Morreale, H. F. (2018). Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nature Reviews Endocrinology, 14(5), 270-284. ‏

 Esteves, S. C., Yarali, H., Ubaldi, F. M., Carvalho, J. F., Bento, F. C., Vaiarelli, A., Alviggi, C. (2020). Validation of ART calculator for predicting the number of metaphase II oocytes required for obtaining at least one euploid blastocyst for transfer in couples undergoing in vitro fertilization/intracytoplasmic sperm injection. Frontiers in endocrinology, 10, 917. ‏

 Faramarzi, A., Khalili, M. A., Agha-Rahimi, A., & Omidi, M. (2017). Is there any correlation between oocyte polarization microscopy findings with embryo time lapse monitoring in ICSI Program. Archives of gynecology and obstetrics, 295(6), 1515-1522. ‏

 Khandgawi, M. A., Morsi, A. N., & Mohamed, L. H. (2016). The relationship of E2/T ratio as an indicator of the aromatase activity with levels of estradiol, testosterone and BMI in Sudanese women with polycystic ovary syndrome. European Journal of Biomedical, 3(6), 166-168. ‏

 Neri Q V, Nigel P, Cozzubbo T, Rosenwaks Z, Palermo GD. Intracytoplasmic sperm injection: Technical aspects. In: Textbook of Assisted reproductive techniques, DK Gardner, A Weissman, CM Howles, Z Shoham. 2012. Pp:141–185.

 Nikbakht, R., Mohammadjafari, R., Rajabalipour, M., & Moghadam, M. T. (2021). Evaluation of oocyte quality in Polycystic ovary syndrome patients undergoing ART cycles. Fertility Research and Practice, 7(1), 1-6. ‏

 Puttabyatappa, M., & Padmanabhan, V. (2018). Ovarian and extra-ovarian mediators in the development of polycystic ovary syndrome. Journal of Molecular Endocrinology, 61(4), R161-R184. ‏

 Qiao, J. & Feng, H. L. (2011). Extra-and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence. Human Reproduction Update, 17(1), 17-33. ‏

 Rajani, S., Chattopadhyay, R., Goswami, S. K., Ghosh, S., Sharma, S., & Chakravarty, B. (2012). Assessment of oocyte quality in polycystic ovarian syndrome and endometriosis by spindle imaging and reactive oxygen species levels in follicular fluid and its relationship with IVF-ET outcome. Journal of Human Reproductive Sciences, 5(2), 187. ‏

 Ranjzad, F., Mahban, A., Shemirani, A. I., Mahmoudi, T., Vahedi, M., Nikzamir, A., & Zali, M. R. (2011). Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome. Journal of Assisted Reproduction and Genetics, 28(3), 225-232. ‏

 Sigala, J., Sifer, C., Dewailly, D., Robin, G., Bruyneel, A., Ramdane, N., ... & Decanter, C. (2015). Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study. Fertility and Sterility, 103(1), 112-118. ‏

 The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long‐term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004; 19(1): 41–47.



How to Cite

Khalial G, Abdulhameed W, Al-Dujaily S. Effects of Activin A Hormone on Fertilization Capacity of PCOS Women Undergoing ICSI Cycle in Sample of Iraqi Women. IJEIR [Internet]. 2020 Aug. 8 [cited 2024 Apr. 20];10(2):14-2. Available from: https://ijeir.net/index.php/ijeir/article/view/66



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