The Effect of BMI on Serum and Follicular Fluid Level of Kisspeptin in Infertile Women

Ghada Alanssari; Mufeda  Jwad; Amal  Mohammed

doi:10.28969/IJEIR.v10.i2.r5.20

Authors

Ghada Alanssari High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.
Mufeda Ali Jwad High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.
Amal Abdulwahid Mohammed High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.

DOI:

https://doi.org/10.28969/IJEIR.v10.i2.r5.20

Keywords:

Kisspeptin, BMI, Infertile women, ICSI

Abstract

Kisspepetin is considered as a key regulator of reproduction, through its direct role in controlling the hypothalamic pituitary gonadal axis necessary for controlling the ovulatory process and indirectly by impacting glucose heamostasis and metabolism. To study the correlation between body mass index and level of Kisspeptin in serum and follicular fluid. This study is a cross sectional study done on (80) infertile Iraqi patients aged (18-40 years) scheduled for fresh intracytoplasmic sperm injection cycle. This study is conducted in the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies of Al-Naharin University, from September 2020 to May 2021. For each participant, the GnRH antagonist protocol was used to hyperstimulate the ovaries, and samples from serum and follicular fluid were obtained at day of oocytes retrieval for measuring Kisspeptin level using enzyme linked immunosorbent assay (ELIZA) technique. Serum and follicular fluid Kisspeptin were insignificantly increasing with the increase in the BMI (p value =0.406) (p value = 0.352) respectively. Serum and follicular kisspetin were positively and significantly correlated (r = 0.536, p value= 0.000). Serum Kisspeptin and follicular Kisspeptin level showed no significant difference among different BMI categories in infertile females undergoing fresh ICSI cycle. Serum Kisspeptin was significantly correlated with follicular fluid Kisspeptin.

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Author Biographies

Ghada Alanssari, High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.

She received her MBChB from the college of medicine, from the University of Baghdad in 2002. She got her Arab board of family medicine in 2016, and her M.Sc. in applied embryology from the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University in 2021. She worked as a rotator in the Baghdad health hospital from 2002- 2005. She worked in different primary health centers in Baghdad from 2011 till 2019. She is a member of the general medical council of England.

Mufeda Ali Jwad, High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.

She received her MBChB. From the College of Medicine at the University of Baghdad in 1996. Her M.Sc. in Applied Embryology and her Ph.D. in Infertility and Clinical Reproduction were from the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University in 2007 and 2018 respectively. She worked as a rotator in the Baghdad health department from 1996-1999. She worked in Gyn. & Obs. in Alsamawa general hospital and Babylon hospital from 2000-2003. She worked at the Babylon University, College of Medicine, anatomy and embryology department from 2003-2004. She has been working as a specialist physician and a consultant clinic at the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University from 2008-2015. Currently, she is an assistant professor and specialist in infertility and clinical reproduction. She is the head of the clinical reproductive physiology department from 2019 till now. She has more than 25 published articles in national and international journals.

Amal Abdulwahid Mohammed, High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.

the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University

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