Correlation between post-tamoxifen hormonal changes and seminal fluid analysis parameters improvement


  • Ali Abdulkhaleq The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies
  • Ula AL-kawaz The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies



tamoxifen, oligoasthenoteratospermia, FSH, testosterone


Oligoasthenoteratozoospermia is a prevalent cause of male infertility.
(iOAT). It is generally acknowledged that, due to the fact that
spermatogenesis is a sex-hormone-dependent process, specific endocrine
treatments might enhance or recover male fertility. The typical negative
feedback of sex steroids is disrupted by anti-estrogen medication, leading to
a rise in endogenous gonadotropin-releasing hormone secretion (FSH and
LH) straight from the pituitary. The stimulation of Leydig cells in the testes
by FSH and LH is thought to promote local testosterone synthesis, which in
turn may improve spermatogenesis. The study sample consisted of 42 iOAT
patients. Baseline seminal fluid analysis (SFA) and hormonal assessment
(FSH, LH, prolactin, and testosterone) were taken. Each patient was given
medical treatment with tamoxifen (20 mg/day) for three months. SFA, FSH,
and testosterone were taken after three months. There was a significant
increase in FSH, testosterone, sperm concentration, and progressive motility
after treatment (p value <0.001), furthermore, there was no significant
correlation between hormonal changes and changes in SFA study markers
(p value > 0,05). Improvements in hormone levels following tamoxifen
treatment for patients with idiopathic oligoasthenoteratospermia do not
correlate with alterations in SFA markers.


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How to Cite

Abdulkhaleq A, AL-kawaz U. Correlation between post-tamoxifen hormonal changes and seminal fluid analysis parameters improvement. IJEIR [Internet]. 2020 Aug. 8 [cited 2024 Apr. 20];10(2):1-13. Available from:



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