Intra cytoplasmic sperm injection (ICSI) outcome comparison among normal, poor and hyper responder females following controlled ovarian stimulation using GnRH antagonist protocol.


  • Muhjah Falah The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies
  • Wasan A. Abdulhameed The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies



sponse, Normal response, ICSI.


The aim of any given ICSI cycle is to achieve normal response and avoid poor
or hyper response. A part from ovarian hyper stimulation syndrome (OHSS),
pregnancy rate in hyper responder females usually low which could be related
to the adverse effect of hyper estrogenic state on oocytes, embryos quality and
uterine endometrium. To evaluate the effect of hyper response on ICSI
outcome represented by oocytes, embryos quality, fertilization and pregnancy
rates. Study showed that total number of retrieved oocytes, mature, immature
oocytes, total embryos, good quality embryos and blastocyst count were
significantly higher in hyper followed by normal and poor responders
respectively. Fertilization rate was significantly higher in both hyper and
normal responders than poor ones, while pregnancy rate was significantly
higher in hyper responders 47.6% followed by normal 40.7% and then poor
ones 16.7%. Conclusions: Irrespective of abnormal hormonal milieu,
excessive ovarian response and higher number of produced oocytes improve
ICSI outcome in hyper responder females by increasing the chance of getting
higher number of embryos, good quality embryos and even blastocyst
numbers which in turn increase the chance of pregnancy


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How to Cite

Falah M, A. Abdulhameed W. Intra cytoplasmic sperm injection (ICSI) outcome comparison among normal, poor and hyper responder females following controlled ovarian stimulation using GnRH antagonist protocol. IJEIR [Internet]. 2020 Aug. 8 [cited 2024 Apr. 20];10(2):51-74. Available from:



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