Correlation of progesterone and activin A with pregnancy outcome following IVF/ICSI cycle


  • Noor Salam The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies
  • Saad S. AL-Dujaily The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies
  • Wasan Adnan Al-Jubory The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies



Intra Cytoplasmic Sperm Injection ICSI, Activin-A, Assisted Reproductive Technologies (ART)


The association between the two hormones (progesterone and Activin A)
in infertile women on the day of ova pick up and their relationship with
pregnancy status in assisted reproductive programs are both poorly
understood. To determine the correlation of progesterone and activin A on
the day of ova pick up with pregnancy status of women undergoing IVF/ICSI
cycle .The study was conducted on 80 infertile couples. The serum at day of
ova pick up was collected. Serum progesterone and activin A analysis were
done for all samples for activin A. Out of eighty infertile females twenty-five
became pregnant (Pregnancy rate = 31%). Serum progesterone levels at days
of oocytes pick up was significantly higher in pregnant females than nonpregnant (9.22 ± 0.54 vs. 4.47 ± 0.44; p < 0.001). There was a significantly
higher serum activin levels at day of oocytes pick up in pregnant women
compared to non-pregnant (2.19 ± 0.04 vs. 1.52 ± 0.04; p < 0.001). The cutoff value of serum progesterone at day of oocytes picks up was > 7.5 ng/ml
and the cut-off value of serum activin A at day of oocytes pick up was > 1.85
ng/ml .Pregnant women had higher levels of the hormone progesterone and
Activin A than non-pregnant women, which is significantly correlated. This
result can be utilized to predicate the pregnancy status early in IVF Centers.



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How to Cite

Salam N, S. AL-Dujaily S, Adnan Al-Jubory W. Correlation of progesterone and activin A with pregnancy outcome following IVF/ICSI cycle. IJEIR [Internet]. 2023 Nov. 8 [cited 2024 Apr. 20];13(2):26-38. Available from: