Single Dose of Granulocyte-Colony Stimulating Factor Use to Improve Intracytoplasmic Sperm Injection Outcomes
DOI:
https://doi.org/10.28969/IJEIR.v13.i1.r5.23Keywords:
G-CSF, Infertility, ImplantationAbstract
Receptive endometrium is essential for successful embryo implantation
and is created by the synergistic activities of estrogen and progesterone, as
well as support from other endocrine, paracrine, and autocrine pathways.
Granulocyte Colony Stimulating Factor (G-CSF) may play a crucial role in
modulating the immune response to enhance implantation. To estimate the
role of granulocyte-colony stimulating factor on the clinical intracytoplasmic
sperm injection (ICSI) outcome parameters. A prospective comparative study
with random sample selection was carried out from 2021 to 2023 at the High
Institute for Infertility Diagnosis and Assisted Reproductive Technologies,
Al-Nahrain University. It included 80 women with infertility, with or without
previous failure trials of intracytoplasmic sperm injection, who completed
IVF and ICSI protocols and reached the day of embryo transfer. On the day
of embryo transfer, patients were divided into two groups: 49 patients
received no additional treatment (group 1), and 31 patients received
granulocyte-colony stimulating factor subcutaneous injection within one hour
of embryo transfer (group 2). The implantation rate was 13.3% in group 2
compared to 7.6% in group 1. The chemical and clinical pregnancy rates were
29.0% and 25.8% in group 2, while group 1 had 18.4% for both chemical and
clinical pregnancy rates. The pregnancy and implantation rates were slightly
higher in group 2, but the difference was not significant. More research is
needed to support the use of G-CSF as a standard treatment in ICSI patients
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